FAQs

What is hepcidin?

Hepcidin, a small 25 amino acid peptide hormone made in the liver, is the principal regulator of systemic iron homeostasis.

How does hepcidin regulate iron?

Hepcidin inhibits cellular iron transfer to blood plasma by binding to and inducing internalization of the sole known iron exporter ferroportin, which delivers iron to blood plasma from iron absorption in the intestine and iron recycling by macrophages. Hepcidin regulates extracellular iron in response to changes in dietary and systemic iron, anemia, hypoxia, inflammation, and erythropoiesis.

To learn more about iron disorders, click here.

Do patients need to fast for the Intrinsic Hepcidin IDx™ Test?

We recommend a sample from a fasting patient, a first morning sample after the 8-12 hours fast. If that is not possible, avoiding iron rich meals and iron supplements is recommended before the sample collection visit.

Does the test need to be ordered by a physician?

Yes, the test needs to be ordered by a physician before the blood sample is collected and sent for testing. The completed Laboratory Requisition form should accompany each sample.

What types of samples are acceptable for testing?

Serum samples are preferable (collected in either in gold top or yellow top tube), Li-Heparin plasma sample are also acceptable (collected in green top tube). EDTA plasma samples (lavender top tube) are acceptable, but we generally do not recommend them, unless this is the only available option for a send out laboratory.

Do you provide kits for blood collection?

We do not provide the kits for blood collection at this time. Please refer to Sample Collection and Shipping Instructions

What are your business hours?

Monday-Friday, 9 am-5 pm.  We are closed during federal holidays.

Who receives test results?

The physician, the patient or the patient’s guardian, or a person authorized by the patient.

How long will it take for the physician to receive test results?

The typical turnaround time is 10 business days. The results may be provided faster if requested by the ordering physician. Patients should also allow time for the physician to review results prior to scheduling a follow up visit.

What is the normal (reference) range for Hepcidin test?

Please refer to Intrinsic Hepcidin IDx Test Specifications page for normal (reference) ranges, depending on gender and sample type.

What other tests are needed to assess iron disorders?

The physician will utilize hepcidin collectively with additional diagnostic tests, as deemed appropriate, to help manage iron disorders.

Billing: are tests from IntrinsicDx™ covered by insurance?

Presently the Intrinsic Hepcidin IDx™ Test is not covered by insurance and there is no CPT code. Thus the cost of the Intrinsic Hepcidin IDx™ Test will be billed directly to the patient or institution. We accept payments by check and credit card. All other tests offered by IntrinsicDx are reimbursed by all major insurance providers

Where can I learn more about Hepcidin?

Please see the list of selected publications here.